I would go and see them to say hello. Make sure they know that you are building the house to live in yourself and that you're not a developer. Ask about schools, village life, pub etc etc. so they know you intend becoming part of the local community. Find out a bit about them and what they do for a living. Tell them you will try to keep any noise and disruption down to a minimum etc.
I would mention that you plan to change the design and reassure them you don't plan to build anything ugly or out of keeping (unless you do!). To some extent you can joke that the design won't be entirely down to you as the planners have so much say these days. I blamed the planners for a change that I secretly wanted and got away with it.
You will probably have to go down the pre-application advice route with the planners. Most likely the planners will want to see some initial drawings and these will get iterated and changed a few times. I would NOT involve the neighbours in this discussion phase at all. Don't send them copies of any drawings.
Once you get to the stage where you are ready to submit the formal application then I WOULD go see the neighbours. Take a set of drawings with you. Do it in person. I think this is better than letting them find out your application has gone in and having to get their own drawings.
Our architect created a "street scene" drawing and some pen an ink/watercolour sketches that showed what the house would look like from the road. This included trees and hedges that obscure part of the house and gave a much better impression than the raw elevations. We left the neighbour with the best of these sketches not the elevation drawings.