The former can be easier. Typically each bathroom has a "stack" which is a vertical 110mm pipe in a corner. Pipes for the WC, shower and basin connect into this. The bottom of the stack under ground has a large radius vertical bend. The top of the stack either goes up through the roof and is vented to the outside or it terminates on the inside with an Air Admittance Valve. The AAV stops fast flowing water in the pipework sucking water out of the shower or WC trap.
For rooms on the ground floor we sometimes run one 110mm pipe direct to the WC. 40/50mm pipes go out through a wall into a gulley. The challenge for this approach is getting the 110mm pipe for the WC in the right place. If it's too close to the wall the toilet seat might not stay up.
If you want a walk in shower (or no plinth under it) special care and planning is needed when laying the slab.