Have you looked at loft legs? They could raise the height to give you more space for ducting, cables and insulation. It will reduce height though. I am not sure why you are proposing membrane.
It depends on the inspector. Since this is for your own occupation it won't come back to bite them so they could be OK. You may need to properly cap off the waste pipes sufficient to do a soil pressure test. Do you need warranty approval / mortgage drawdown? They may be a bit more picky for this. You need electric completion cert and you will also need an airtightness test so see what state they will accept.
Use the fattest stud that will fit through the holes. Use the plate as a template. 100mm depth in the concrete should be fine and 2mm bigger diameter than the studs. Either a blow out tool or a hose to clean the holes.