Reading this thread is only serving to show that a gas boiler is not the best mate for under floor heating. I know conventional wisdom says if you have mains gas, use it as it is the cheapest form of heat.
For low temperature under floor heating, an ASHP makes a much better companion. My own system is about as keep it simple as you can get. the ASHP drives the UFH directly, no buffer, and a small 5KW ASHP will happily supply water at 37 degrees and modulate down to very low levels to maintain that, and running at low temperatures like that gives good efficiency from a heat pump.
I still think there is merit in individual room thermostats. We only have 3 heating zones, the big kitchen / diner space, the living room and (not yet fitted) the utility room. All loops are fed from the same temperature water from the same manifold and pretty much the same flow rates to each loop, but the kitchen / diner is the last room to reach temperature and shut off. That is simply because so much of that room does not have UFH e.g not under kitchen units or the island, not under the stove, and not under the corner of the room that will eventually be the pantry. So probably 1/4 of that room does not have heating pipes under it, so it is now wonder it takes a little longer than the other room to heat up.
I have used the dry biscuit mix screed as the heat spreader medium under our wooden floors downstairs and am very happy with it. Upstairs, just in the bathrooms I have UFH with spreader plates and this does not seem as effective to me, but then again the heat has to get through the wooden floor, the wet room tanking membrane then the tiles so it is probably no wonder we get less effective heating there.
Lastly with the level of insulation you will have, you WILL need separate control for the bedrooms, much of the time they won't need any heat at all, we don't have bedroom heating, but you can achieve that by just valving off the upstairs manifold as a single zone if you don't want individual room control.