If you are using low heat levels to cover the heat being lost - you run the heating 24/7 - you can add a little setback if you want to bedrooms at night or fit trvs and cap the bedroom temps that way but the issue with setbacks is you need to run a higher temp to recover from the setback period
My house bedrooms are at 18, living areas 20 and bathrooms 21 - all other areas are between 16 and 19
house is far more comfortable than heating am and PM in timed slots and the cost difference for me is an extra £60 a year - I’m happy to pay that because I can do that on a good night on the beer!!!!