Thanks for the input all some good thoughts.
We have 3 pannel radiators on 22/15mm pipe from the wood boiler, so moving to ashp they should be ok, they're sized ok (having modeled on heatpunk at a 40-45c flow rate).
The house is 800mm stone wall. The floor 3 is stone, insulation, brick with well insulated rafters. The inner floors are non insulated concrete slab. Though I had considered insulating between 2/3.
Each floor is about 85m2 mostly ontop top of one another.
So yes, perhaps just ways heating the loft works out. Intend to run the system open with no buffer, it's a large system. Was more to shut off supply to floor 3 when not in use.
Thanks the the modulation tables and cycling information, I figure I can work out system volume and see.