manifold control for radiators without TRVs

For room-by-room temperature controls, Viallant's smart systems (and many others) are using wireless TRVs to turn on of each radiators flow.

We are planning to install a combi boiler (Viallant 938?) with a manifold system for radiators so we will have ports for each rooms flow-return and each port can have actuators which is a smiliar to the multi zone underfloor heating control concept.

In this setup, I prefer the radiators would not have TRVs but the rooms will have their own thermostats and the manifold ports will have actuators.

There are concerns  about the total run of pipes from manifolds so a pumped manifold can be used to ease the flow but also concerns about turning on/off the actuators for room controls that might not work with the combis efficient modulating and smart features.

So whats your suggestion and experiences in a similar setup? which thermostat and wiring system can we use efficiently parellel to the boilers smart features to control the temperatures room by room ?

Or is there better way (with or without TRVs) to have multiple zone (room-by-room) centralised controls of the manifold radiator heating system?