Following some excellent tips and pointers from @PeterW, @AliG and others on this site, I'm starting to think that I need to reconsider the location of my unvented indirect hot water tank.
My question is: in an ideal world, if you have a three storey house, with the boiler on the bottom storey, the two main bathrooms on the middle storey and an extra bathroom that will only get used at weekends on the top storey, on which storey should the unvented indirect hot water tank be sited, or does it not matter? Does gravity have an impact? I guessed gravity wouldn't matter when hot water is going from the boiler to the cylinder, but that gravity would help when water is going from the cylinder to the rest of the house and on that basis, and the fact I wanted to be efficient with use of space, I planned on having the cylinder in the loft. But that is just my guesswork, as my builder is yet to introduce me to his truant heating engineer.
Should the cylinder actually be nearer the boiler to reduce heat loss along the journey between the two, or can that just be mitigated with pipe insulation? The boiler could probably go in the loft as well - it doesn't have to go in the ground floor.