Thanks Guys, lots of very helpful content. To try and fill in some of the gaps this is where I've got to so far:
House is about 220m2 on a south facing plot in Shropshire. Lot of glazing on the south side (including a 5.5m x 2.4m slider) but design features a balcony to act as a brise soleil for ground floor and roof overhang to protect first floor from overheating. Architect has confirmed there is less than 2% chance of any overheating. There is a risk this design has overdone the shading so I potentially may lose some of the winter heat upside!
Current plan is for EPS raft foundation with a U value of about 0.11, trussed warm roof should be about 0.12
Preferred supplier for Windows has Uw value of 0.79, Slider will be 1.1, entrance doors about 1.0., and there are 6 rooflight that will be 0.1.
Design includes MVHR and target is to achieve high levels of air tightness. I'm learning that detail here is the key and probably my weakest link as I plan to use a local builder for much of the work so will be a challenge to ensure attention to detail.
So, with all these elements pretty much decided I'm trying to settle the question of just how low do I need to go for the walls. For the ICF option the difference between 0.15 and 0.12 is only about £5k for block supply and I'm assuming labour etc. will be the same for either. The other difference is in wall thickness and I will lose about 75mm which is OK if there is a real benefit in the lower U value, otherwise it would be nice to keep the extra space if the higher value is sufficent. Not yet managed to get to the same level of analysis for the TF options but I guess it will come down to the same trade-off.