Thanks @JohnMo for the response.
I'm definitely not sure on any of my working assumptions or calculations - this is definitely all new to me! The figures I quoted for system capacities per floor were based on Passihaus supply recommendations that are higher than regs, include occupancy and factor the HRU at only 70% loading - so probably way over the top. Meanwhile, BPC calculated the house airflow rate based solely on UK regs and for the floor area they measured at 129m2, as 38.7 l/s, which I believe is 139.32m3/h. Against this, the Vent Axia Econiq S that they recommended has 350m3/h capacity, so a 40% loading, (possibly because it's the smallest model in that range).
Thanks too regarding cascade systems, I did investigate this after reading your comments in other threads. My understanding from some of the papers referenced suggested that this approach works where the path of least resistance can be forced to cascade through targeted rooms and not be short-circuited by easier routes from supply to the nearest extract, Unfortunately, both floors of our 'classic' 3-bedroom semi have all supply & extract rooms directly off the hall, stairs & landing area, so every potential cascade route would be shorted out. Our ducting challenges lie less with the horizontal aspect of getting to the room vents duct so much as the need for vertical 'risers' on the first floor. I did look at using floor vents for bedrooms to avoid the risers, but I'd worry that they'd get covered, draughty and/or with, no chance of Coanda effect, fail to diffuse, and just ventilate the route straight across the floor to the door.
Regarding dMEV/MEV, I will look at this if I can't get MVHR to work, but I'd prefer to deliberately supply fresh, filtered & pre-warmed air to living rooms and bedrooms alongside extraction. I'm sure our house is miles from airtight but I take heart in the conclusion of the 2020 Passivhaus Case for MVHR paper that concludes with the following...